DA-1726
Obesity is a complex disease in which excessive body fat increases due to nutrient imbalance. Obesity is a medical problem requiring interventional treatment to manage and minimize the risk of other heal-th problems, such as diabetes, high blood pressure, and heart disease, etc.
DA-1726 is a long acting oxyntomodulin peptide analog that can bind and activate both glucagon-like peptide-1 (G-L-P-1) and glucagon receptors. Activation of G-L-P-1 and glucagon receptors suppresses appetite and reduces nutrient intake.
In addition, activation of glucagon receptors in adipose tissue elicits fat burning. Thus, DA-1726, designed as a well-balanced dual agonist, induces wei-ght loss while effectively improving body composition.
Moreover, hypoglycemic effects induced by G-L-P-1 receptor activation were maintained. DA-1726 has a well understood mechanism of action, and, in pre-clinical mice models, resulted in improved wei-ght loss compared to semaglutide (Wegovy®) and cotadutide (another OXM analogue).
Additionally, in pre-clinical mouse models, DA-1726 elicited similar wei-ght reduction, while consuming more food, compared to tirzepatide (Zepbound®) and survodutide (a drug with the same MOA), while also preserving lean body mass and demonstrating improved lipid-lowering effects compared to survodutide.
In the Phase 1 multiple ascending dose (MAD) trial in obesity, the 32 mg dose of DA-1726 demonstrated best-in-class potential for wei-ght loss, glucose control, and waist circumference reduction.
Vanoglipel (DA-1241)
Vanoglipel (DA-1241) is a novel G protein-coupled receptor 119 (GPR119) mainly in the pancreas, intestine, and liver.
In non-clinical studies, GPR119 activation by vanoglipel in hepatocytes, macrophages, and hepatic stellate cells inhibits lipid accumulation, immune cell infiltration, and the production of collagen fibers in the liver, directly ameliorating MASH pathophysiology such as steatosis, inflammation, and fibrosis.
Moreover, GPR119 has a distinctive role in glucose and lipid metabolism via stimulating secretion of insulin and glucagon-like peptide-1 (G-L-P-1) in pancreatic beta cells and intestinal L-cells, respectively.
Therefore, vanoglipel can also provide additional metabolic benefits in MASH patients with common comorbid metabolic diseases such as type 2 diabetes and dyslipidemia.
In Phase 1b clinical trials, the safety and efficacy of DA-1241 monotherapy were successfully confirmed. Vanoglipel was well-tolerated in type 2 diabetic patients.
In a Phase 2a clinical study, vanoglipel demonstrated direct hepatic action in addition to its glucose lowering effects.
Uncover Sources And More Here: MTVA Website. MTVA Presentation. -----
5 Explosive Potential Catalysts Put (Nasdaq: MTVA) On Radar Watch
#1. MTVA Has A Low Float (Volatility Potential Could Be Explosive).
With a float of roughly 3.31Mn shares, according to the Yahoo Finance website, volatility potential could pop up in a flash.
#2. An Analyst Target From Zacks Small-Cap Research Suggests MTVA To Have Significant Upside Potential From Current Chart Levels.
In March, Zacks Small-Cap Research analyst David Bautz provided MTVA with a massive target of $30.
From Friday's open, that target represents a potential 2,300+% upside.
Here are some report highlights:
OUTLOOK
On March 26, 2026, MetaVia, Inc. (MTVA) announced financial results for the fourth quarter and full year 2025 and provided a business update. The company expects to initiate the Phase 1 Part 3 trial of DA-1726, a dual oxyntomodulin analog that functions as a glucagon-like peptide-1 receptor (G-L-P1R) and glucagon receptor (GCGR) agonist, in April 2026. This will be a 16-week titration study to evaluate 48 mg (1-step) and 64 mg (2- step) DA-1726 in obese but otherwise healthy adults. We anticipate topline results from the study in the fourth quarter of 2026. The company recently completed a public offering that generated $9.3Mn in gross proceeds, which will finance operations into the fourth quarter of 2026. -----
Furthermore, a Maxim Group analyst target of $8 is also on our radar.
From Friday's open, that target represents a more than potential 500% upside.
#3. MetaVia Expands Clinical Momentum Advancing DA-1726 Toward Transformative Obesity Treatment Success.
MetaVia Inc. has received IRB approval to advance Part 3 of its Phase 1 trial for DA-1726, a dual GLP-1 and glucagon receptor agonist showing best-in-class potential for weight loss and glucose control.
The new studies will test higher 48 mg and 64 mg doses using one- and two-step titration regimens in obese but otherwise healthy adults.
Earlier results demonstrated 9% wei-ght lo-ss and strong metabolic benefits with excellent safety.
With dosing set to begin in April, MetaVia anticipates results by late 2026, reinforcing DA-1726’s next-generation therapeutic promise.
#4. Strategic Intellectual Property Milestones Strengthen MetaVia Pipeline Globally.
MetaVia Inc. is significantly strengthening its long-term position in cardiometabolic and liver disease by building durable global patent estates around vanoglipel and DA-1726.
With 48 patents and applications protecting vanoglipel across major markets through 2035, MetaVia secures broad coverage for composition, manufacturing, and use in MASH, diabetes, and other metabolic liver diseases.
An additional 39 patents and applications protect DA-1726 for obesity and metabolic disease through 2041, reinforcing MetaVia’s commercial optionality in a rapidly expanding therapeutic category.
Together, these assets showcase MetaVia’s focused strategy to maximize pipeline value and patient impact.
#5. MetaVia Announces Positive AI-Modeling Results from its Ongoing Syntekabio Collaboration, Confirming Key Therapeutic Targets for Vanoglipel.
MetaVia reported promising results from its partnership with Syntekabio, where AI modeling using the DeepMatcher® platform validated key therapeutic targets for its GPR119 agonist, vanoglipel (DA‑1241).
The analysis confirmed strong engagement across inflammatory and cardiometabolic pathways, aligning with MetaVia’s focus on MASH and potential type 2 diabetes treatments.
These findings, alongside positive Phase 2a results showing improved liver and glucose function with good safety, strengthen MetaVia’s confidence in vanoglipel’s broader therapeutic potential and highlight the power of AI in its development strategy. -----
Coverage is kicked-off on MetaVia Inc. (Nasdaq: MTVA).
When updates are available, we'll get them out quickly.
All the best, Dane James Editor Market Pulse Today
(Remember: St-ock Prices Could Be Significantly Lower Now From The Original Dates I Provided.)
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